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Britain's health minister Wes Streeting announced Thursday that he had resigned, paving the way for him to launch a leadership challenge against embattled Prime Minister Keir Starmer.In his resignation letter to Starmer, which Streeting posted on X, he said: "It is now clear that you will not lead the Labour Party into the next general election".He added that he had "lost confidence" in Starmer's leadership, and a debate about what comes next for the ruling party "needs to be broad, and it needs to be the best possible field of candidates".Streeting, 43, did not say whether he had the required support of 81 Labour MPs — 20% of the party in parliament — to trigger a contest.Starmer, who led his Labour party to victory in 2024 elections ending 14 years of Conservative rule, is fighting to save his job after disastrous local and regional polls last week.Four junior ministers have resigned and more than 80 Labour MPs have urged him to quit, but he has vowed to cling on and more than 100 lawmakers from the ruling party have called for him to stay.Thursday, his former deputy Angela Rayner announced that UK tax authorities had "cleared" her of deliberate wrongdoing in a tax affair, opening the way for her to compete in a potential leadership race.The 46-year-old insisted she would not be the one to trigger a contest, but told the Guardian newspaper she would play "whatever role I can" to "deliver the change".Rayner, a left-wing figurehead hugely popular among Labour's grassroots activists, also called on Starmer to "reflect" on his position.She was forced to step down in September for underpaying a property duty, but said Thursday the UK tax authority HMRC had exonerated her of "the accusation that I deliberately sought to avoid tax".Rayner quit as deputy PM and housing, communities and local government minister after an investigation found she had breached the ministerial code over the purchase of a flat in southern England. Media reported she had paid off £40,000 ($54,000) in outstanding tax.Local poll drubbingStreeting is popular on the right of Labour, but is disliked by MPs on the left who would prefer Rayner or Greater Manchester Mayor Andy Burnham as leader.Burnham is currently blocked from running as he does not have a seat in the Westminster parliament. His supporters want Starmer to set a detailed timetable for his departure that allows Burnham to stand.Starmer's spokesman insisted Thursday that the prime minister was going nowhere.He "is purely focused on governing. He is getting on with the job of doing just that," the spokesman told reporters.Voters last week punished Starmer over his 22 months in power in local ballots which saw huge gains for the hard-right Reform UK party and the left-wing populist Greens at Labour's expense.The Labour Party lost control of the devolved Welsh parliament for the first time and failed to make up ground on the pro-independence Scottish National Party (SNP) in the parliament in Edinburgh.Rayner earlier stopped short of calling for Starmer to resign, but said voters were frustrated with the way the government was being run.Starmer has vowed to fight any contest and came out fighting on Monday, pledging to do better and prove his doubters "wrong".He has been backed by several senior cabinet ministers, including Finance Minister Rachel Reeves, who urged colleagues Thursday not to put the economy "at risk" by "plunging the country into chaos" with a leadership challenge. 

In a significant step to further strengthen Qatar’s position in healthcare innovation, the Department of Laboratory Medicine and Pathology (DLMP) at Hamad Medical Corporation (HMC) has officially launched Whole Exome Sequencing (WES) testing. This groundbreaking initiative represents a major advance in genetic diagnostics, enabling patients in Qatar to receive faster, more accurate diagnoses and highly personalised treatment plans tailored to each individual’s genetic profile. This new testing technology will benefit patients with genetic disorders, both adults and children, as well as those with certain types of cancer. Previously, blood samples for these patients had to be sent abroad for testing, a process that often required significant time before results could be obtained. WES is a cutting-edge genetic test that focuses on the exome, the regions of DNA responsible for coding proteins. Since most disease-causing mutations are found in these regions, WES provides powerful insights into unexplained illnesses, inherited conditions, and genetic risks affecting families. To conduct the test, a blood sample is collected, DNA is extracted, and advanced sequencing technology is used to analyse the exome. Sophisticated computer software then interprets the data, highlighting possible genetic causes of disease. Chair of DLMP at HMC, Dr Einas Abdulaziz al-Kuwari, stated: "This initiative underscores our commitment to integrating genomic medicine into patient care. By harnessing advanced sequencing technologies, we aim to provide more precise and timely diagnoses." She added: "This will transform the management of genetic conditions in Qatar and empower physicians to deliver truly personalised care tailored to each patient’s unique genetic profile." "The launch of WES at HMC fulfils a long-held vision to bring genomic medicine into routine clinical care in Qatar. We are no longer dependent on external laboratories; today we can deliver advanced diagnostics right here in-house," she added. Al-Kuwari stressed: "This achievement is not only scientific but a message of hope for families living with genetic conditions. It symbolises Qatar’s determination to stand at the forefront of precision medicine, building a healthcare system that is both world-class and compassionate." "And this is only the beginning. We will continue to advance until every patient in Qatar has access to the most innovative care possible,” added al-Kuwari. Under the leadership of Dr Moza Khalifa al-Kuwari, and supported by a highly skilled team of national specialised laboratory staff, the Molecular Genetics Laboratory within DLMP’s Diagnostic Genomic Division (DGD) spearheads the introduction of WES testing. The process has been validated according to international standards, including those of the American College of Medical Genetics and Genomics (ACMG) and the College of American Pathologists (CAP). To ensure seamless integration, DLMP has invested in robust data infrastructure, including secure high-capacity servers, advanced computing power, and state-of-the-art cybersecurity, to safeguard sensitive information and enable rapid data analysis. The introduction of this advanced service will also help reduce the need to send patient samples abroad for genetic testing. Established in 2001, the Molecular Genetics Laboratory is among the region’s most advanced facilities, performing approximately 30,000 genetic tests annually and supporting national screening programmes, including premarital and newborn screening. Accredited by the College of American Pathologists (CAP) since 2014, the laboratory continues to uphold the highest international standards. With the introduction of WES, HMC consolidates its leadership in genomic medicine, delivering cutting-edge care for patients while strengthening Qatar’s healthcare infrastructure.