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For 124 years, the Nobel Prize has stood as one of the world’s most respected distinctions, recognising discoveries and ideas that advance humanity. The prize was founded by Alfred Nobel, the Swedish chemist, engineer and industrialist whose inventions in explosives, including dynamite and safer detonation systems , built a vast international fortune. In his will, Nobel directed that this wealth should be used to honour individuals who had “conferred the greatest benefit to humankind”, turning personal success into a global legacy of progress. On 10 December, the anniversary of Alfred Nobel’s death, the world honours the 2025 Nobel Laureates. Nobel Day has become a defining moment in international recognition, celebrating achievements in science, literature, economic thought and peacebuilding. The 2025 awards speak directly to the challenges shaping the modern era: the defence of democracy, advances in medical research, breakthroughs in quantum physics, climate-relevant materials, deeper insights into innovation and a literary voice that captures the anxieties of contemporary life. From María Corina Machado’s struggle for democratic freedoms to discoveries in immunology, chemistry, physics and economics, and the visionary writing of László Krasznahorkai, the 2025 Nobel Prizes illustrate what becomes possible when knowledge, creativity and courage converge. The 2025 laureates, announced in October, are celebrated at a moment of political strain, rapid scientific progress and global transformation. Nobel assigned the Peace Prize to Norway’s Parliament because, at the time he wrote his will, Sweden and Norway shared a union but had separate governments. Norway’s reputation for diplomacy made it, in his view, the most credible guardian of a prize dedicated to peace. That tradition continues today: the Peace Prize is presented in Oslo, while all other Nobel Prizes are awarded in Stockholm in the presence of His Majesty King Carl XVI Gustaf of Sweden.The 2025 Nobel laureates and their motivations**media[391542]**Nobel Peace Prize:Democracy defended in VenezuelaMaría Corina Machado receives the Peace Prize for her determined efforts to restore democratic freedoms in Venezuela. Despite intimidation, political exclusion and exile, she has become a leading figure in peaceful resistance to authoritarian rule. Her recognition underscores global concerns about the fragility of democratic institutions.Nobel Prize in Literature:The visionary voice of László KrasznahorkaiHungarian novelist László Krasznahorkai is honoured for his compelling and visionary body of work. His long, flowing prose and themes of collapse, transformation and spiritual unrest have shaped contemporary literature across Europe, Asia and the Americas.Nobel Prize in Medicine:Understanding the immune system’s self-controlMary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi receive the Medicine Prize for pioneering discoveries on regulatory T cells, the immune system’s mechanism for preventing attacks on the body’s own tissues. Their work has reshaped modern immunology and opened new avenues for treating autoimmune disease, cancer and transplant rejection.Nobel Prize in Physics:Quantum mechanics at human xcaleJohn Clarke, Michel H. Devoret and John M. Martinis are recognised for demonstrating quantum tunnelling and energy quantisation in macroscopic electrical circuits. Their findings proved that quantum effects extend far beyond the microscopic realm and laid the foundation for superconducting qubits, accelerating efforts to develop practical quantum computers.Nobel Prize in Chemistry:Materials for a climate-challenged centurySusumu Kitagawa, Richard Robson and Omar M. Yaghi are awarded the Chemistry Prize for developing metal–organic frameworks, or MOFs, a class of materials with immense internal surface area and critical environmental applications. MOFs have become central to carbon capture, hydrogen storage and water harvesting, making this research vital in a climate-constrained world.Prize in Economic Sciences:Innovation as the engine of prosperityJoel Mokyr, Philippe Aghion and Peter Howitt receive the Prize in Economic Sciences for theories explaining how technological innovation drives long-term economic growth. Their work clarifies why societies prosper when they embrace new ideas, offering insights that resonate strongly in an age defined by artificial intelligence, automation and global economic change. From democracy and literature to immunology, quantum physics, climate-focused chemistry and the economics of innovation, the 2025 Nobel Prizes reflect the most pressing questions of our time. They also reaffirm Alfred Nobel’s vision: that human progress depends on curiosity, creativity and the courage to challenge accepted limits. Awarded for more than a century, the Nobel Prizes continue to define what the world values most. In 2025, they once again highlight the individuals whose ideas and achievements are helping shape the future.

Scientists' work relates to 'how we keep immune system under control'Work spurred development of treatments in areas such as cancer, autoimmune diseaseMore than 200 trials on humans involving regulatory T cells under wayFirst award in 2025 Nobel Prizes, Physics next on TuesdayAmerican scientists Mary Brunkow and Fred Ramsdell and Shimon Sakaguchi from Japan won the 2025 Nobel Prize in Physiology or Medicine on Monday for work shedding light on how the immune system spares healthy cells, creating openings for possible new autoimmune disease and cancer treatments.Their discoveries relate to peripheral immune tolerance, or "how we keep our immune system under control so we can fight all imaginable microbes and still avoid autoimmune disease", said Marie Wahren-Herlenius, a rheumatology professor at Sweden's Karolinska Institute, the awarding body.The institute said all three laureates brought to the fore so-called regulatory T cells, a class of white blood cells that act as the immune system's security guards that keep immune cells from attacking our own body.Brunkow, who found out she had won after being woken by her dog barking at a news photographer on the front porch of her Seattle home, said she, Ramsdell and their colleagues had isolated a gene called FOXP3 that could be used as a marker for the cells."They're rare, but powerful, and they're critical for sort of dampening an immune response," she said in an interview, describing the cells as a braking system that prevents the body's immune system from tipping over into attacking itself.Sakaguchi expressed surprise at a press conference in Osaka, western Japan, because he felt any major recognition would have depended on more development advances."I used to think that some sort of reward may be forthcoming if what we have been doing will advance a little further and it will become more beneficial to people in clinical settings," he said in a calm voice, cracking a smile now and then.The press conference was interrupted for Sakaguchi to take a congratulatory phone call from Japanese Prime Minister Shigeru Ishiba, who asked him how effective immunotherapy could be for cancer treatment in the future."I believe the time will come when cancer is no longer a scary disease, but a curable one," said Sakaguchi.The winners of the award are selected by the Nobel Assembly of the Karolinska Institute, a leading medical university, and receive a prize sum of 11 million Swedish crowns ($1.2 million), as well as a gold medal presented by Sweden's king.Brunkow is senior programme manager at the Institute for Systems Biology in Seattle, while Ramsdell is scientific adviser at Sonoma Biotherapeutics in San Francisco. Sakaguchi is a professor at Osaka University.Jeffrey Bluestone, a decades-long friend of Ramsdell and a co-founder with him of Sonoma Biotherapeutics, told Reuters that his associate's extraordinary contribution was finding the FOXP3 gene, initially in mice, that controlled the development of regulatory T cells. They described their findings in a paper in 2001."Those cells were the master regulators of the tolerance of the immune system," said Bluestone.Ramsdell could not be reached by Reuters - nor by Brunkow or Bluestone, with Bluestone saying he may be on a hiking trip in an area without cell phone reception.After announcing the winners, the Karolinska Institute's Thomas Perlmann said specific therapies had yet to win market clearance but more than 200 trials on humans involving regulatory T cells were ongoing.Among companies in the early race, Ramsdell's Sonoma Biotherapeutics is partly funded and supported by US drugmaker Regeneron to work on therapies against diseases including inflammatory bowel disease.Also targeting that condition, Quell Therapeutics has partnered with AstraZeneca. Other biotech firms exploring the approach include Bayer's BlueRock.The Nobel Prizes were established through the will of Alfred Nobel, the Swedish inventor of dynamite and a wealthy businessman.They have been awarded since 1901 for outstanding contributions in science, literature, and peace. The economics prize was added later and is funded by Sweden's central bank.Winners are selected by expert committees from various institutions. All prizes are awarded in Stockholm, except for the Peace Prize, which is presented in Oslo.Past recipients of the Nobel Prize in Physiology or Medicine include renowned scientists such as Alexander Fleming, who shared the 1945 award for discovering penicillin. In recent years, the prize has recognized major breakthroughs, including those that enabled the development of COVID-19 vaccines.Last year's medicine prize was awarded to US scientists Victor Ambros and Gary Ruvkun for their discovery of microRNA and its key role in how multicellular organisms grow and live.Medicine in accordance with tradition kicks off the annual Nobels. The physics award is next, on Tuesday.The awards culminate in ceremonies attended by the royal families of Sweden and Norway, followed by lavish banquets held on December 10 - the anniversary of Alfred Nobel's death.