Covid-19 research offers hope amid a grim scenario
September 12 2021 11:00 PM

The latest updates on Covid-19 research offer some hope amid a continuing grim scenario precipitated by the pandemic.
The highlights are that an arthritis drug cuts death risk in high-risk patients, some heart drugs might help prevent Covid-19 blood clots and Mu variant’s escape from antibodies may inform vaccine research.
They include research that warrants further study to corroborate the findings and that have yet to be certified by peer review.
Hospitalised Covid-19 patients at high risk for becoming critically ill and dying had significantly better outcomes if they received the anti-inflammatory drug anakinra, researchers have found.
To test the drug, sold as Kineret by Sweden’s Sobi Inc, the researchers looked for patients with high blood levels of a protein called suPAR, which is linked to higher odds of needing mechanical breathing assistance and death from Covid-19.
The 594-patient trial showed the risk of death was 55% lower in patients who received anakinra, and 80% lower for the sickest patients in the trial, the researchers reported in Nature Medicine.
The clinical benefit with anakinra treatment was already apparent from day 14, and this is of clinical importance because the first 14 days is the period during which a patient is expected to worsen.
Anakinra benefit was maintained until day 28.
Measuring suPAR allows for a more personalised treatment approach, but its use to guide Covid-19 treatment could be problematic because the tests are not available in every hospital.
Drugs that prevent blood clots after procedures to unclog heart arteries might also be useful for clot prevention in patients with Covid-19, new data suggests.
The coronavirus is known to affect genes that control platelets, fragments in the blood that form clots.
The inflammatory proteins generated by the virus cause platelets to become “hyperreactive” and form clots more easily and more often.
In test tube experiments described last Wednesday in Science Advances, researchers found that anticoagulants used after coronary stenting — clopidogrel, sold as Plavix by Bristol Myers Squibb and Sanofi, and ticagrelor, sold as Brilinta by AstraZeneca — keep Covid-19 patients’ platelets from becoming over-activated by blocking the P2Y12 protein on their surface.
If additional studies confirm their findings, these P2Y12 inhibitors “may represent a particularly attractive therapy” for reducing the risk of inflammation-related blood clots in Covid-19, the authors say.
The ability of the Mu variant of the coronavirus to escape from antibodies and vaccines can aid in preparations against other emerging variants, Japanese researchers say.
The variant has driven outbreaks in Colombia and is now classified as a “variant of interest” by the World Health Organisation, although it appears unlikely to overtake the far more prevalent Delta variant.
In test tube experiments, researchers found that Mu is “highly resistant” to antibodies in blood samples from Covid-19 survivors and from people who got the mRNA vaccine from Pfizer and BioNTech.
In fact, the spike used by the virus to break into cells was more resistant to neutralisation than all other currently recognised variants of interest and variants of concern, the researchers reported last Tuesday ahead of peer review.
Dr Eric Topol of the Scripps Clinic in La Jolla, California, who was not involved in the research, noted in a tweet on Wednesday that Delta’s high infectiousness surpasses Mu’s ability to escape from antibodies.
Nevertheless, study co-author Kei Sato of the University of Tokyo said understanding how variations in spike proteins affect the potency of neutralisation antibodies is important for developing new vaccines and predicting breakthrough infections.

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