"Endgame," released in theaters in April, is the culmination of a story told in 22 Marvel films that have drawn crowds to cinemas for a decade.
The movie stars Robert Downey Jr., Chris Hemsworth, Scarlett Johansson and others as a group of superheroes battling the villain Thanos, played by Josh Brolin.
Marvel Studios President Kevin Feige told fans at Comic-Con that "Endgame" was poised to reach the box office milestone. He also said "Endgame" probably would eventually lose the title to Cameron's next film.
Cameron is scheduled to release four "Avatar" sequels starting in December 2021. Disney this year acquired the "Avatar" franchise with its purchase of film and TV assets from Rupert Murdoch's 21st Century Fox.
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