But exhaustive testing by fire and hazardous material teams found no toxic material, said Jon Johnston, fire marshal for the city of Menlo Park in California where Facebook is based.
"There is no sarin," he told Reuters, referring to the package that had erroneously tested positive on Monday morning.
Facebook routinely checks all packages and had initiated a standard safety protocol, Johnston added, saying teams worked into the early hours of Tuesday to clear the scene.
Federal Bureau of Investigation (FBI) agents also went to the scene, Facebook said. A Facebook spokesman confirmed the all-clear on Tuesday.
"Authorities have confirmed test results were negative for any potentially dangerous substance and the buildings have been cleared for repopulation," said Anthony Harrison, Facebook's director of corporate media relations.
With 2.3 billion monthly active users worldwide and more than $55 billion in revenue in 2018, Facebook faces criticism for its control of personal information and has been subject to cyber attacks.
In December, a bomb threat at its main campus in Menlo Park forced the evacuation of several buildings. No bomb was found.
Sarin was used in a 1995 attack by a Japanese cult on the Tokyo subway that killed 13 people and injured several thousand.
Syria's government has denied recent accusations that it used sarin against insurgents during their civil war.
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