Ryanair faces a one-day walkout by cabin crew across five countries on September 28 as unions step up pressure on Europe's biggest budget airline to accept local contracts.
The threatened strike in Belgium, Italy, the Netherlands, Portugal and Spain is aimed at pressuring shareholders set to meet on September 20 to address Ryanair's labour agreements, union officials said on Thursday.
They said unions would strike once a month until their demands are met.
"It is time the company accepted to employ us with local contracts under local conditions in accordance with local law," Didier Lebbe, a spokesman for the CNE union in Belgium, told a news conference in Brussels.
"We need shareholders to change Ryanair's employment model," he said, and called for European political mediation.
Ryanair employs staff across Europe under Irish contracts, but some unions want the ability to negotiate terms under the employment laws of their own country.
Belgian unions forecast most flights out of Ryanair's two airports in Belgium will be cancelled, challenging the company's pledge to minimise disruptions.
Some pilots in Italy will also join the industrial action on the day, the Uiltrasporti union said.
A spokesman for Ryanair said "there will be no pilot strike in Italy", adding that Ryanair had already signed a collective labour agreement with the ANPAC union and does not recognise the "small" Uiltrasporti union.
Unions representing three of the airline's Italy-based cabin crews said in a statement on Thursday they had agreed in principle to a three-year collective labour agreement.
Fit Cisl, Anpac and Anpav unions signed Thursday's agreement, but Uiltrasporti was not mentioned.
Ryanair has struggled to curb an industrial relations revolt in recent months and was forced to cancel 150 of its 400 German flights on Wednesday after a walkout by pilots and crew.
Chief Executive Michael O'Leary said in response that the airline, which flies some 2,500 flights a day, was willing to accept strikes if that was the cost of defending its low-cost business model.
Ryanair suffered its worst ever strikes this summer after slow progress in negotiating collective labour agreements with pilots and cabin crew.
In August it reached a deal with striking Irish pilots, but unions representing pilots and cabin crew in Germany have threatened further walkouts if Ryanair does not improve offers on terms and pay.