Flash flooding hit towns and villages in the East Riding of Yorkshire and north-east Lincolnshire.
There was a metre of standing water in parts of Withernsea and further flooding in the Grimsby and Immingham areas.
Humberside fire and rescue service said it responded to calls on Tuesday evening from Bridlington down to Hull, and from towns south of the river Humber.
Social media users posted pictures of stranded cars on the road into Flamborough; Melanie Onn, the Labour MP for Great Grimsby, shared pictures on Twitter of the waterlogged roads, saying that some were “like a river” and that the water was “over my ankles”.
With forecasts that up to 80mm of rain could fall in parts of the country over the next 24 hours, the Met Office has warned that more flooding of homes and businesses is possible.
A yellow weather warning for rain has been issued for parts of the UK, including the East Midlands, West Midlands, London, East Anglia and the south-east.
In some places 0.8in to 1.2in is predicted to fall within two or three hours. “An area of heavy rain will sink slowly southwards across the east and south-east of England,” said the Met Office.
“Some transport routes may be affected by localised flooding, leading to longer journey times. In addition, flooding of homes and businesses is possible. The heaviest of the rain should gradually become confined to the extreme south-east of the UK later in the day.”
The Environment Agency is expecting the river Leen in Nottinghamshire to flood, while areas around the North Sea coast at Scarborough have been put on alert.
The warnings come three weeks after heavy rain lashed the country and led to flash flooding in the Cornish coastal village of Coverack.
Fifty properties were affected and several people had to be rescued from their homes.