* UN alarmed at death toll, says dozen killed, hundreds injured
* Iraqi advances open escape routes for Mosul civilians
* US-trained units aim to isolate IS in Old City pockets
* Baghdad hopes to declare Mosul victory during Eid holiday
* More than 20 killed, wounded in east Mosul suicide bombings
Iraqi forces opened exit routes for hundreds of civilians to flee the Old City of Mosul on Saturday as they battled to retake the ancient quarter from Islamic State militants mounting a last stand in what was the de facto capital of their "caliphate".
US-trained urban warfare units were channelling their onslaught along two perpendicular streets that converge in the heart of the Old City, aiming to isolate the jihadist insurgents in four pockets.
The United Nations voiced alarm on Saturday at the rising death toll among civilians in the heavily populated Old City, saying as many as 12 were killed and hundreds injured on Friday.
"Fighting is very intense in the Old City and civilians are at extreme, almost unimaginable risk. There are reports that thousands, maybe even tens of thousands, of people are being held as human shields (by Islamic State)," Lise Grande, the UN humanitarian coordinator in Iraq, said in a statement. "Hundreds of civilians, including children, are being shot."
Iraqi authorities are hoping to declare victory in the northern Iraqi city in the Muslim Eid holiday, which marks the end of the fasting month of Ramadan, during the next few days.
Helicopter gunships were assisting the ground thrust, firing at insurgent emplacements in the Old City, a Reuters correspondent reported from a location near the front lines.
The government advance was carving out escape corridors for civilians marooned behind Islamic State lines.
There was a steady trickle of fleeing families on Saturday, some with injured and malnourished children. "My baby only had bread and water for the past eight days," one mother said.
At least 100 civilians reached the safety of a government-held area west of the Old City in one 20-minute period, tired, scared and hungry. Soldiers gave them food and water.
More than 100,000 civilians, of whom half are believed to be children, remain trapped in the crumbling old houses of the Old City, with little food, water or medical treatment.
The urban-warfare forces were leading the campaign to clear the Sunni Islamist militants from the maze of Old City alleyways, moving on foot house-to-house in locations too cramped for the use of armoured combat vehicles.
Aid organisations and Iraqi authorities say Islamic State was trying to prevent civilians from leaving so as to use them as human shields. Hundreds of civilians fleeing the Old City have been killed in the past three weeks.
A US-led international coalition is providing ground and air support in the eight-month-old campaign to seize Mosul, the largest city the militants came to control in a shock offensive in Iraq and neighbouring Syria three years ago.
US-supported Iraqi government offensives have wrested back several important urban centres in the country's west and north from Islamic State over the past 18 months.
Historic mosque blown up by militants
Military analysts said Baghdad's campaign to recover Mosul gathered pace after Islamic State blew up the 850-year-old al-Nuri mosque with its famous leaning minaret on Wednesday.
The mosque's destruction, while condemned by Iraqi and UN authorities as another cultural crime by the jihadists, gave troops more freedom to press their onslaught as they no longer had to worry about damaging the ancient site.
It was from the mosque that Islamic State leader Abu Bakr al-Baghdadi announced himself to the world for the first time as the "caliph", or ruler of all Muslims, on July 4, 2014. Mosul's population at the time was more than 2 million.
Baghdadi fled into the desert expanse extending across Iraq and Syria in the early phase of the Mosul offensive, leaving the fighting there to local IS commanders, according to US and Iraqi officials. Recent Russian reports that he was killed have not been confirmed by the coalition or Iraqi authorities.
The Iraqi government once hoped to take Mosul by the end of 2016, but the campaign dragged on as IS reinforced positions in inner-city neighbourhoods of the city's western half, carried out suicide car and motorbike bomb attacks, laid booby traps and kept up barrages of sniper and mortar fire.
By this weekend, the area still under IS control was less than 2 square km (0.77 sq miles) in extent, skirting the western bank of the Tigris River that bisects Mosul.
Islamic State retaliated for government advances on Friday evening with a triple bombing in a neighbourhood in eastern Mosul, which Baghdad's forces recaptured in January. The attack was carried out by three people who detonated explosive belts, killing five, including three policemen, and wounding 19, according to a military statement on Saturday.
The fall of Mosul would mark the end of the Iraqi half of Islamic State's "caliphate" as a quasi-state structure, but IS would still hold sizeable, mainly rural and small-town tracts of both Iraq and Syria.
In eastern Syria, Islamic State's so-called capital, Raqqa, is now nearly encircled by a US-backed Kurdish-led coalition.
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