"I like Oprah," Trump said, adding that he had appeared on her long-running afternoon program.
"I know her very well," he said, before adding: "I don't think she's going to run."
Winfrey's rousing speech at Sunday's Golden Globes Awards ceremony ignited speculation that the billionaire chat show queen is harboring Oval Office ambitions.
Some Democrats -- still reeling from their shock loss to Trump in 2016 -- have embraced the idea of having their own celebrity leader.
But there is little indication that the 63-year-old actually wants the job.
"I don't think at this point she is actually considering it" said Winfrey's best friend Gayle King, who is also a television personality.
"I also know, after years of watching the Oprah show, you always have the right to change your mind."
