Pakistan were bowled out for 198 in reply to England's first innings 589 for eight declared, a huge deficit of 391 runs, on the third day of the second Test at Old Trafford on Sunday.
Despite the mammoth lead, England captain Alastair Cook decided against enforcing the follow-on.
All-rounder Chris Woakes took four for 67, while Joe Root followed his first innings 254, his Test-best score, with four catches at second slip.
Pakistan lead the four-match series 1-0 after their 75-run win in the first Test at Lord's last week.
England were 11 without loss in their second innings, a lead of 402 runs, when rain forced an early tea on the third day.
Alastair Cook, the England captain, was nine not out and Alex Hales two not out.
Scoreboard
England 1st Innings 589-8 dec (J Root 254, A Cook 105, C Woakes 58, J Bairstow 58; Wahab Riaz 3-106)
Pakistan 1st Innings (overnight: 57-4)
Mohammad Hafeez c Root b Woakes 18
Shan Masood c Root b Anderson 39
Azhar Ali c and b Woakes 1
Younis Khan c Bairstow b Stokes 1
Rahat Ali c Ballance b Woakes 4
Misbah-ul-Haq c Cook b Ali 52
Asad Shafiq c Hales b Broad 4
Sarfraz Ahmed c Root b Stokes 26
Yasir Shah c Root b Woakes 1
Wahab Riaz c Hales b Ali 39
Mohammad Amir not out 9
Extras (lb2, nb2) 4
Total (all out, 63.4 overs, 286 mins) 198
Fall of wickets: 1-27 (Hafeez), 2-43 (Azhar), 3-48 (Younis), 4-53 (Rahat), 5-71 (Masood), 6-76 (Shafiq), 7-112 (Sarfraz), 8-119 (Yasir), 9-179 (Misbah), 10-198 (Wahab)
Bowling: Anderson 13-5-27-1; Broad 12-5-20-1 (1nb); Ali 7.4-0-43-2 (1nb); Woakes 16-1-67-4; Stokes 15-1-39-2
Misbah-ul-Haq plays a shot on the third day of the second Test against England at Old Trafford on Sunday.
