Opinion
Weight loss key to type 2 diabetes remission: study
A new analysis in The Lancet Diabetes & Endocrinology found that nearly 80% of type 2 diabetics who lost 30% of their body weight achieved complete remission
March 02, 2025 | 11:16 PM
The medical fraternity has always highlighted the fact that being overweight brings added risks for type 2 diabetics. A new analysis published in The Lancet Diabetes & Endocrinology reiterates that the more weight people with type 2 diabetes lose, the greater the odds that the disease will go partially or even completely into remission. Reviewing 22 earlier randomised trials testing weight loss interventions in overweight or obese patients with type 2 diabetes, researchers found complete remission of the disease in half of those who lost 20-29% of their body weight. Nearly 80% of patients who lost 30% of body weight no longer appeared to have diabetes.That means their haemoglobin A1c levels – a standard measure reflecting average blood sugar levels over the past few months – or their fasting blood sugar levels had returned to normal without use of any diabetes medications. No one who lost less than 20% of their body weight achieved a complete remission, but some were in partial remission, with haemoglobin A1c and fasting glucose levels returning almost to normal. Partial remission was seen in roughly 5% of those who lost less than 10% of their body weight, and that percentage rose steadily with greater weight loss, reaching nearly 90% among those who lost at least 30%.Overall, for every one percentage point decrease in body weight, the probability of reaching complete remission increased by roughly two percentage points and the probability of reaching partial remission increased by roughly three percentage points, regardless of age, sex, race, diabetes duration, blood sugar control, or type of weight loss intervention. Type 2 diabetes accounts for 96% of all diagnosed cases of diabetes, and more than 85% of adults with the disease are overweight or obese, the researchers noted. "The recent development of effective weight loss medications, if made accessible to all who could benefit, could play a pivotal role” in reducing the prevalence of diabetes and its complications, they added.According to the World Health Organisation (WHO), the number of people living with diabetes rose from 200mn in 1990 to 830mn in 2022. Prevalence has been rising more rapidly in low- and middle-income countries than in high-income countries. More than half of people living with diabetes did not take medication for their diabetes in 2022. Diabetes treatment coverage was lowest in low- and middle-income countries.Diabetes causes blindness, kidney failure, heart attacks, stroke and lower limb amputation. In 2021, diabetes and kidney disease due to diabetes caused over 2mn deaths. In addition, around 11% of cardiovascular deaths were caused by high blood glucose. A healthy diet, regular physical activity, maintaining a normal body weight and avoiding tobacco use are ways to prevent or delay the onset of type 2 diabetes. Diabetes can be treated and its consequences avoided or delayed with diet, physical activity, medication and regular screening and treatment for complications.The key contributors to the rise in type 2 diabetes include: urbanisation, an ageing population, decreasing levels of physical activity, and increasing overweight and obesity prevalence. However, it is possible to reduce the impact of diabetes by taking preventive measures for type 2 diabetes and providing early diagnosis and proper care for all types of diabetes. Type 1 diabetes (previously known as insulin-dependent, juvenile or childhood-onset) is characterised by deficient insulin production and requires daily administration of insulin. In 2017 there were 9mn people with type 1 diabetes; the majority of them live in high-income countries. Neither its cause nor the means to prevent it are known, WHO has said.
March 02, 2025 | 11:16 PM