The first fighters from the last rebel bastion in Eastern Ghouta left on Sunday for insurgent-held territory in the country's northwest, state media said, raising hopes of an end to conflict in the enclave.
More than 600 civilians have been killed in the enclave outside Damascus since Russia-backed regime forces launched an assault on February 18.
More than 300 people have been killed in the rural eastern Ghouta district on the outskirts of Damascus since Sunday night, and many hundreds have been wounded, according to human rights monitors.
Fresh regime strikes killed 15 civilians Wednesday in a rebel-held enclave near Damascus where overwhelmed medics were still treating the survivors of the Syrian conflict's bloodiest day in months.
More than 3,000 people left the rebel enclave of Aleppo on Monday, raising hope for many others still stranded, as Russia eased its objections to sending UN observers to oversee the evacuations.