The Washington-led alliance puts the toll at just over 1,000 civilians in both Syria and neighbouring Iraq, and says it does all it can to prevent civilian deaths.
Doctors and medics in two hospitals in Hodeida province said 50 people have been killed in the past 24 hours, seven of them pro-government fighters.
The US assessment comes after a string of high-profile coalition strikes that have killed scores of civilians, many of them children.
The bombing on a crowded market in rebel-held northern Yemen killed a total of 51 people, according to the Red Cross.
A roadside bomb which hit a bus in restive western Afghanistan on Tuesday killed at least eight people and wounded around 40, mostly women and children, officials said.
This came on Friday in the statement delivered by HE Permanent Representative of Qatar to the United Nations Ambassador Sheikha Alya Ahmed bin Saif al-Thani at the official meeting of the UN Security Council.
There were two explosions near the city's directorate of finance, the Nangarhar provincial governor's spokesman Attaullah Khogyani said, adding that "a number of attackers" had entered the building.
The first fighters from the last rebel bastion in Eastern Ghouta left on Sunday for insurgent-held territory in the country's northwest, state media said, raising hopes of an end to conflict in the enclave.
More than 600 civilians have been killed in the enclave outside Damascus since Russia-backed regime forces launched an assault on February 18.
HE the Official Spokesperson of the Foreign Ministry Lulwa al-Khater said that "Eastern Ghouta is one of the de-escalation zones, and these operations could hinder international efforts to reaching a political solution."
Five civilians were killed and another 18 wounded in central Mali when their passenger vehicle struck a landmine, the local governor said on Saturday, two weeks after 26 travellers died in a similar incident ...