The Syrian army has retaken nearly all the farmland in Eastern Ghouta under cover of near ceaseless shelling and air strikes, leaving only a dense sprawl of towns still under insurgent control.
Angela Merkel said: "The killing of children, the destruction of hospitals -- all that amounts to a massacre that must be condemned and which must be countered with a clear no".
The Kremlin said on Wednesday that Western allegations the Russian Air Force was responsible for civilian deaths in the rebel-held district of eastern Ghouta outside the Syrian capital Damascus were groundless.
Eastern Ghouta is now the last opposition-controlled pocket around Damascus and Syrian President Bashar al-Assad has dispatched reinforcements there in an apparent bid to retake it.
Two Palestinians were killed by Israeli fire, Gaza medical sources said on Sunday, after four soldiers were wounded in an apparent bomb attack on the border with the Palestinian enclave.
French Defence Minister Florence Parly on Friday called for an end to air strikes in Syria and the opening of humanitarian corridors, saying it was unacceptable that civilians were being targeted.
Air strikes killed 31 civilians including 12 children in the rebel-held Eastern Ghouta region near Syria's capital Damascus on Wednesday, the Syrian Observatory for Human Rights said.
Regime air strikes killed 28 civilians in a rebel enclave near Damascus on Monday as Syria's seven-year-old conflict raged on several fronts with non-combatants paying a heavy price.
Saudi-led air strikes on a prison camp run by rebels in Yemen killed 12 people and wounded 80 on Wednesday, the rebels' Al-Masirah TV reported.